Alexander Misharin, MD, PhD
Associate Professor, Medicine, Pulmonary Division; Feinberg School of Medicine
Research Program
Cancer-Focused Research
I am a trained immunologist with a focus on macrophage biology. My group demonstrated that lung injury leads to accumulation and life-long persistence of monocyte-derived alveolar macrophages, which retain activated phenotype for months after the injury, thus, contributing to lung aging per se and increasing susceptibility to other age-related lung diseases, such as pulmonary fibrosis and lung cancer. We utilize both mouse models as well as human samples. My group holds expertise in multi-parameter flow cytometry and cell sorting, as well as transcriptomic profiling via bulk and single-cell RNA-seq. I serve as a member of advisory board for the Robert Lurie Cancer Research Center Flow Cytometry Core Facility, which serves numerous cancer researchers at Northwestern. We also actively collaborate and provide our help and expertise to the members of the Cancer Center (Ali Shilatifard, Jaehyuk Choi).